Description
Product Characteristics:
The chondroitin N-acetylgalactosaminyltransferase family includes Beta-1,4-GalNAc-T, Beta-1,4-GalNAc-T2, Beta-1,4-GalNAc-T3 and Beta-1,4-GalNAc-T4. The Beta-1,4-GalNAc-T protein consists of a short N-terminal residue, a transmembrane region and a long C-terminal residue, which includes a catalytic domain and localizes to the Golgi apparatus. Beta-1,4-GalNAc-T utilizes simple ganglioside GM3 as a substrate for more complex gangliosides GM2, GM1 and GD1a. Beta-1,4-GalNAc-T is expressed in normal brain tissues and in various malignant transformed cells, such as malignant melanoma, neuroblastoma and adult T cell leukemia. Mice lacking the Beta-1,4-GalNAc-T protein develop significant and progressive behavioral neuropathies, including deficits in reflexes, strength, coordination and balance. Beta-1,4-GalNAc-T is a potential molecular marker for detecting melanoma cells and monitoring tumor progression.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: 4-N-acetylgalactosaminyltransferase 1, Beta4GalNAcT 1, beta4GalNAcT, Beta4GalNAcT-1, Beta4GalNAcT1, CGAT1_HUMAN, ChGn, Chondroitin beta-1, Chondroitin beta1 4 N acetylgalactosaminyltransferase, Chondroitin beta1 4 N acetylgalactosaminyltransferase 1, Chondroitin sulfate N acetylgalactosaminyltransferase 1, Chondroitin sulfate N-acetylgalactosaminyltransferase 1, CSGalNAcT 1, CsGalNAcT-1, Csgalnact1, FLJ11264, FLJ13760.
Target Information: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage